“This is the first cancer study to harness this drug-food interaction,” the authors note.
Grapefruit juice plus#
Those taking sirolimus plus grapefruit juice needed between 25 and 35 mg of sirolimus per week.
Patients taking sirolimus plus ketoconazole needed only 16 mg per week to maintain the same levels of drug in the blood. The optimal doses for the other two groups were much lower. At doses above 45 mg, however, the drug caused serious gastrointestinal problems, such as nausea and diarrhea, so patients taking sirolimus alone switched to 45 mg twice a week. The optimal cancer-fighting dose for those taking sirolimus was about 90 mg per week. The first patients started with very low sirolimus doses, but the amounts increased as the study went on, to see how much of the drug was required in each setting to reach targeted levels, so that patients got the greatest anti-cancer effect with the least side effects. They enrolled 138 patients with incurable cancer and no known effective therapy. Patients received only sirolimus, sirolimus plus ketoconazole, or sirolimus plus grapefruit juice. The effect begins within a few hours of what the researchers refer to as “grapefruit juice administration.” It wears off gradually over a few days.Ĭohen and colleagues organized three simultaneous phase-1 trials of sirolimus. Grapefruit juice’s pharmaceutical prowess stems from its ability to inhibit enzymes in the intestine that break down sirolimus and several other drugs. Instead, we wanted to see if grapefruit juice can be used in a controlled fashion to increase the availability and efficacy of sirolimus.”įirst study to harness drug-food interaction “Grapefruit juice, and drugs with a similar mechanism, can significantly increase blood levels of many drugs,” said study director Ezra Cohen, a cancer specialist at the University of Chicago Medicine, “but this has long been considered an overdose hazard.
A drug called ketoconazole that also slows drug metabolism increased sirolimus levels by 500 percent. Patients who drank eight ounces a day of grapefruit juice increased their sirolimus levels by 350 percent. In a study published in August in Clinical Cancer Research, they show that eight ounces a day of grapefruit juice can slow the body’s metabolism of a drug called sirolimus, which has been approved for transplant patients but may also help many people with cancer. Researchers at the University of Chicago Medicine study the effects that foods can have on the uptake and elimination of drugs used for cancer treatment. The combination could help patients avoid side effects associated with high doses of the drug and reduce the cost of the medication. A daily glass of grapefruit juice lets patients derive the same benefits from an anti-cancer drug as they would get from more than three times as much of the drug by itself, according to a new clinical trial.
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